Immunogenicity of Anti-TNF-α Biotherapies: I. Individualized Medicine Based on Immunopharmacological Evidence
نویسندگان
چکیده
منابع مشابه
Immunogenicity of Anti-TNF-α Biotherapies: I. Individualized Medicine Based on Immunopharmacological Evidence
Specific inhibition of the cytokine, tumor necrosis factor-α (TNF), has revolutionized the treatment of patients with several autoimmune diseases, and genetically engineered anti-TNF antibody constructs now constitute a heavy medicinal expenditure in many countries. Unfortunately, up to 30% of patients do not respond and about 50% of those who do loose response with time. Furthermore, safety ma...
متن کاملImmunogenicity of Anti-TNF-α Biotherapies: II. Clinical Relevance of Methods Used for Anti-Drug Antibody Detection
Immunogenicity of biopharmaceuticals is complex and influenced by both structural and pharmacological factors, and by patient-related conditions such as disease being treated, previous and concomitant therapies, and individual immune responsiveness. Essential for tailored therapeutic strategies based on immunopharmacological evidence from individual patients (personalized medicine) is the use o...
متن کاملA review on evidence-based medicine
Physicians’ daily need for valid information about diseases, their limited time for finding this information, the inadequacy of traditional sources (E.g. textbooks) to address this matter, the disparity between physicians diagnostic skills and clinical judgment (Which increase with experience) and their up to date knowledge and clinical performance (Which decline by time), as well as dramatic d...
متن کاملPhilosophical Contemplation on Evidence-Based Medicine
Background and Objectives: Today, the main basis of diagnosis and treatment in medicine is the obtained evidence from the research. One of the movements that have attempted to establish this basis is evidence-based medicine (EBM). The present review dealt with the philosophical assessment of this subject. Methods: In this study, EBM-related data from books and articles were reviewed. Resu...
متن کاملEvidence based medicine in nuclear medicine practice; Part I: Introduction, asking answerable questions and searching for the best evidence
Evidence Based Medicine (EBM) is a new approach to patient management which incorporates best evidence with the clinical expertise of the health care providers. Although this approach has had a rapid growth in many clinical disciplines, its applications in radiology and nuclear medicine has not been addressed sufficiently. In this review EBM is briefly explained...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2015
ISSN: 1664-3224
DOI: 10.3389/fimmu.2015.00152